--- a/configure.ac
+++ b/configure.ac
@@ -687,6 +687,19 @@ case "${host}" in
 	fi
 	zero_realloc_default_free="1"
 	;;
+  *-*-linux-musl*)
+	dnl syscall(2) and secure_getenv(3) are exposed by _GNU_SOURCE.
+	JE_APPEND_VS(CPPFLAGS, -D_GNU_SOURCE)
+	abi="elf"
+	AC_DEFINE([JEMALLOC_PURGE_MADVISE_DONTNEED_ZEROS], [ ], [ ])
+	AC_DEFINE([JEMALLOC_HAS_ALLOCA_H], [ ], [ ])
+	AC_DEFINE([JEMALLOC_PROC_SYS_VM_OVERCOMMIT_MEMORY], [ ], [ ])
+	AC_DEFINE([JEMALLOC_THREADED_INIT], [ ], [ ])
+	if test "${LG_SIZEOF_PTR}" = "3"; then
+	  default_retain="1"
+	fi
+	zero_realloc_default_free="1"
+	;;
   *-*-linux*)
 	dnl syscall(2) and secure_getenv(3) are exposed by _GNU_SOURCE.
 	JE_APPEND_VS(CPPFLAGS, -D_GNU_SOURCE)
--- a/include/jemalloc/jemalloc_macros.h.in
+++ b/include/jemalloc/jemalloc_macros.h.in
@@ -142,7 +142,7 @@
 #  define JEMALLOC_COLD
 #endif
 
-#if (defined(__APPLE__) || defined(__FreeBSD__)) && !defined(JEMALLOC_NO_RENAME)
+#if (defined(__APPLE__) || defined(__FreeBSD__) || (defined(__linux__) && !defined(__GLIBC__))) && !defined(JEMALLOC_NO_RENAME)
 #  define JEMALLOC_SYS_NOTHROW
 #else
 #  define JEMALLOC_SYS_NOTHROW JEMALLOC_NOTHROW